Calutide

What is CALUTIDE and what it is used for?

  - Your medicine, CALUTIDE, contains the active substance bicalutamide,

  - which belong to the group called non-steroidal antiandrogens.

  - Antiandrogens block the action of male

  - Hormones and prevent cell growth in the prostate.

  - CALUTIDE is intended for adult men to treat metastatic prostate cancer that has not spread to other parts of the body.

  - It can be used alone or in combination with other therapies

  - Methods such as surgical removal of prostate or radiotherapy.

  - This medicine should not be used in children and adolescents.

When you should not take CALUTIDE?

  • if you are a woman, child or teen. CALUTIDE treats conditions that occur only in men.

  • if you are allergic to bicalutamide

  • if you are taking terfenadine, astemizole or cisapride

Warnings and precautions:

  - Tell your doctor if you have liver problems (mild or severe liver damage)

  - This medicine should only be given after the doctor has evaluated the risks and benefits of this medicine.

  - If you have any cardiac or vascular disease, including heart rhythm disorders (arrhythmias) or you are being treated for these diseases.

Interaction with other medicines?

 Do not take CALUTIDE if you are already taking any of the following medicines:

  • cisapride (used to treat heartburn and stomach problems)

  • terfenadine or astemizole (used to treat allergies)

Before taking CALUTIDE, please tell your doctor if you are taking or have previously taken CALUTIDE following medicines:

  • Ciclosporin - a medicine used to control the immune system used after organ or bone marrow transplantation

  •  Diltiazem-  calcium channel blockers

  • Oral anticoagulants such as warfarin

  • Cimetidine (to treat stomach ulcers or heartburn);

  • Ketoconazole

  • Midazolam

Driving and using machines

 - This medicine should not affect your ability to drive or use machines.

 -  If you decide to drive or use machines, you should take extra care due to the possible feeling of dizziness.

How to take CALUTIDE?

  • The recommended dose is one tablet once a day.

  • Tablets should be swallowed whole with water with or without food.

  • It is important to take the medicine at the same time each day.

  - If you take more CALUTIDE than you should

  - If you take too many tablets, consult a doctor or nearest emergency department immediately.

  - If you forget to take CALUTIDE

  - Do not take a double dose to make up for a forgotten tablet. Take it an additional dose at a normal time.

What are known side effects?

 • A severe allergic reaction manifested by swelling of the face, lips, tongue and/or throat,

• Yellowing of the skin- jaundice

• Severe deterioration of breathing

• Pneumonia

•  Irregular heart rate

•  Rash

•  Sensitivity or enlargement of breast tissue

•  Weakness

•  Hot flashes

•  Anemia

•  Decrease in appetite

•  Reducing sex drive

•  Depression

•  Headedness

•  Sleepiness

•  Stomach or chest pain

•  Constipation and bloating

•  Digestive problems

•  Nausea

•  Change in liver function, including elevated liver enzymes

•   Hair loss

•   Excessive hair growth or renewed hair growth

•   Dry skin

•   Itchy skin

•   Blood in the urine

•   Difficulty in maintaining or maintaining an erection

•   Swelling of the hands and feet.