Sildenafil Citrate | Drug Info | Interaction, Dosages, Factors, Mechanism

Posted by admin 15/05/2019 0 Comment(s) Erectile Dysfunction,

What is Sildenafil Citrate?

Sildenafil citrate is white crystalline citrate form powder, it use to treatment of erectile dysfunction and aspiratory blood vessel hypertension. Sildenafil citrate is specific phosphodiesterase-5 (PDE5) inhibitor that temporarily normalizes erectile function of penis during sexual action.

What is erectile dysfunction?

Erectile dysfunction (ED) is symptoms, but not diseases, in which man is powerlessness to get or keep an erection firm that, allow sexual activity with penetration. It’s sometimes referred to as feebleness.

Causes of Erectile Dysfunction - Erectile Dysfunction is caused by three ways:

Physical illness:

Erectile dysfunction is frequently connected with conditions that influence blood stream in the penis. Such as

  • Diabetes
  • High cholesterol
  • Hypertension
  • Cigarette smoking
  • Coronary illness
  • Numerous sclerosis
     

Psychological factor:

In which man are effected by stress during sexual drive or performance.

Such as:

  • Mental conditions
  • serious nervousness
  • dread of closeness
  • serious problem related to  work,  financial or relationship
     

Health related factor:

  • Smoking
  • Drinking too much alcoholic beverages
  • Utilizing illicit medications
  • Being overweight
  • Not being physically dynamic
     

How does Sildenafil Citrate works in body?

Sildenafil drug work in the nitric oxide pathway, which work by affecting catalyst action of enzyme in nitric oxide pathway.

Under normal conditions, sexual promote   the    production and release of nitric oxide in the penis. Nitric oxide are activates the guanylate cyclase enzyme, which causes the production of cyclic guanosine monophosphate (cGMP). The chemicals guanylate cyclase then converts guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP).

Sildenafil prevent activity of phosphodiesterase-5type (PDE5) enzyme, which is responsible for the degradation of   cyclic guanosine monophosphate (cGMP) in the corpus cavernosum.  Cyclic cGMP are present inside the blood vessel. This help to widen (relax) blood vessels and improves the flow of blood to the penis following sexual stimulation.

Penile-Erection-and-the-Mechanism-of-Sildenafil-Citrate

Erection:  Main problem of erectile dysfunction

What is erection?

During sexual excitement, nerves discharge chemicals that increase blood stream into the penis. Blood streams into two erection chambers in the penis made of spongy muscle tissue. Blood flow fills the penis and generate blood pressure in the chambers makes the penis firm, causing an erection. At the point when a man has a climax, a second set of nerve signals achieve the penis and cause the achmuscular tissues in the penis to contract and blood is discharge back into a man's circulation and the erection descends.

Sildenafil Interaction:

When sildenafil take with alcohol, food and drug, it may to some positive or negative effect on body.

Sildenafil interaction with alcohol:

Sildenafil can bring down blood pressure, when it interaction with alcohol may   increase this effect.

When you take sildenafil, you should avoid or limited the use amount alcohol.  

When sildenafil interaction with huge amount of alcohol may experience some symptoms such as

  • Dizziness,
  • Cerebral pain,
  • Heart beats.
  • Flushing
  • Lightheadedness
     

Sildenafil interaction with food:

When you take sildenafil therapy you ought to maintain distance from sildenafil affected food

Which type food ought not to take?

  • Oily Foods
  • Nitrates Foods
  • Grapefruit or Pomegranate
  • Rich protein nourishment
     

Certain enzymes are available in grapefruit which prevent sildenafil from breaking down   in the body and delay the time it take for the medication work.

When you taking sildenafil an on full stomach, you experience some following symptoms such as

  • Flushing
  • Cerebral pains
  • Fainting
  • Low pulse
  • Runny or stuffy nose
     

Sildenafil Interaction With Other Drugs

If you take sildenafil with other medication, it makes dangers for body.

You should not take intake with sildenafil the following drugs:

  • Anti-toxins
  • Warfarin
  • Recreational medication
  • alpha blocker drug
     

If you take sildenafil with other drug, you feel following symptoms:

  • Deadly drop in circulatory strain
  • Complexities quick heart rate
  • Influence dimensions of sildenafil in the blood
     

Sildenafil Dosages:

  • 50mg
  • 100mg
  • 150mg
     

Sildenafil might be taken from 4 hours to 0.5 hours before sexual action.

The sildenafil doses are mainly depend on adequacy and toleration, so it may be taken to maximum dose of 100mg or lowest dose to 25mg.

How Long Does It Take For Sildenafil To Take Effect?

Sildenafil begins to work after approximately 30 minutes.

In healthy  volunteers, sildenafil portions are ingested quickly, with most extreme plasma fixations accomplished inside a middle time of 1 h (extend, 0.5– 2 h) in the wake of dosing. The terminal half-existence of sildenafil is 3- 5 hours.

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