Xbira

WHAT IS XBIRA?

  -  XBIRA is an anti-tumor drug, which belongs to a group of drugs called aromatase inhibitors.

  - The drugs of this group act on a substance called aromatase, and it is needed in the production of female hormone estrogens, especially in postmenopausal women.

  -  Reducing estrogen levels in the body is a way the treatment of an estrogen- depending breast cancer XBIRAis not intended for use in children.

THE INDICATION FOR USE:

  - Hormone-dependent early breast cancer in postmenopausal women

  - Hormone-dependent advanced breast cancer in postmenopausal women, when treatments with other hormonal drugs failed.

WHAT DO YOU NEED TO KNOW BEFORE STARTING  A THERAPY?

 Do not take XBIRA if you are:

  - Allergic or have had an allergic reaction to an exemestane

  - Still in a reproductive period

  - Are pregnant or if you are breastfeeding.

WARNINGS AND PRECAUTIONS:

 Inform your doctor  if you are taking:

  • Rifampicin (antibiotic)

  • Carbamazepine or phenytoin

RECOMMENDATIONS  FOR PREGNANCY, BREASTFEEDING, AND  DRIVING:

 You should not take XBIRA if you are pregnant or breastfeeding.

 If you feel sleepy or weak during therapy, do not operate vehicles or machines.

HOW IS XBIRA USED?

- Adults and elderly patients:

- A recommended dose is one tablet or 25 mg daily, taken orally after a meal, at about the same time every day.

·        -  If you take more XBIRAthan you need  contact your doctor immediately or contact your nearest hospital. Take a tablet box with you.

·        -  If you have forgotten to take a therapy do not take a double dose to make up for a forgotten tablet.

WHAT ARE KNOWN  SIDE EFFECTS:

  - Hepatitis

  - Depression

  - Sleeping disorder

  - A headache

  - Waves of heat

  - Nausea

  - Increased sweating

  - Muscle and joint pain (including osteoarthritis, back pain, arthritis and stiffness joints)

  - Reduction in the number of white blood cells (leukopenia)

  - Abdominal pain

  - Elevated levels of liver enzymes

  - Elevated levels of bilirubin in the blood

  - Elevated levels of alkaline phosphatase enzymes in the blood

  - The pain

  - Loss of appetite

  - A sensation of needle-sting and pain affecting the whole hand except a fist o finger- Carpal tunnel syndrome

  - Pain in the stomach, vomiting, constipation, digestive disorders, diarrhea

  - Hair loss

  - Skin rash, rash, and itching

  - Reduction of bone strength which can reduce their strength (osteoporosis),

  - Swelling of the hands and feet

  - A decrease in the number of platelets (thrombocytopenia)

  - General weakness.

  - Hypersensitivity.

  - The emergence of small bubbles in the skin affected by a rash