Sorafenat

ABOUT SORAFNAT?

•   SORAFNAT is used to treat liver, thyroid gland cancer,  kidney cancer inadvanced stage, when the standard therapy wasn’t effective.
•   SORAFNAT’ s mechanism of action is to slow down the growth of cancer cells and interruptions of the blood supply that keeps growing cancer cells.
•   SORAFNAT  is not indicated to use in the pediatric population.

WHAT ARE WARNING AND  RECOMMENDATIONS?

 You should inform your therapist if you have :

•    Skin problems
•    High blood pressure
•    Bleeding problems or take warfarin or phenprocoumon
•    Chest pain or heart problems
•    Heart disorders
•    If you need to have surgery or have recently been operated
•    Receive a drug irinotecan or docetaxel
•    If you are taking neomycin or another antibiotic.
•    Severe damage to your liver function.
•    Kkidney disorder
•    Gastrointestinal perforation

THE INTERACTION WITH OTHER DRUGS?

 Inform your doctor if you are taking, you have recently taken the following medicines:

•    Rifampicin, neomycin
•    Phenytoin, carbamazepine or phenobarbital, epilepsy
•    Dexamethasone,
•    Warfarin used to prevent the blood clots forming
•    Doxorubicin, capecitabine, docetaxel, paclitaxel, and irinotecan
•    Digoxin.

Pregnancy and breastfeeding

•   If you are pregnant your doctor will decide whether to continue therapy.
•   Do not SORAFNT during lactation.
•   Vehicle handling and machine handling
•   SORAFNAT doesn’t affect the ability to drive or use machines.

HOW TO USE SORAFNAT?

  The adults:

- The recommended dose of SORAFNAT  is 800 mg daily, swallowed whole with sufficient amounts of water, at about the same time each day.

YOU SHOULD BE AWARE OF THE POSSIBLE SIDE EFFECTS LIKE:

•    Diarrhea
•    Nausea
•    Fatigue
•    Pain (including pain in the mouth, abdominal pain, headache, bone pain, pain caused by the tumor)
•    Hair loss
•    Red or painful palms or soles
•    Itching or rash
•   Vomiting
•    Bleeding
•    High blood pressure
•    Infections
•    Anorexia
•    Constipation
•    Pain in the joints
•    Fever
•    Dry throat
•    A flu-like syndrome
•    Difficulty digesting and swallowing
•    Inflammation of the mucous membrane of the mouth and
•    Muscle pain
•    A disorder of the sensation in the fingers of the hands and feet
•    Depression
•    Impotence
•    Dermatitis
•    Heart attack
•    Kidney weakness
•    Reduction in the number of white, red cells and blood plates
•    Hypothyroidism
•    Flashes of redness accompanied by the feeling of heat
•    Skin cancer
•    Involuntary muscle contraction
•    Gastritis
•    Allergic reactions
•    Dehydration
•    Breast enlargement
•    Difficulty in breathing
•    Eczema
•    Increased thyroid gland activity
•    Numerous changes in the skin
•    Gastrointestinal perforation