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Poxet (Dapoxetine) is indicated for premature ejaculation (PE). Its mechanism of action is preventing serotonin re-uptake so as to modify the reflex that controls ejaculation.

Poxet 60 mg tablet contain dapoxetine 60 mg, a selective serotonin re-uptake inhibitor (SSRI) that is used specifically for premature ejaculation (PE), as it has a rapid onset of action, with maximum effect within 1-2 hours and a short half-life, which means that it is rapidly eliminated from the body within 24 hours. 

Ejaculation is a reflex that is mediated by the sympathetic nervous system. When sexual stimulation has reached a certain threshold, sensory nerve cells in the spinal cord are activated and nerve impulses are sent to the brain, which then send messages back to motor neurones controlling the muscles in the penis that contract to effect ejaculation. 

The ejaculation reflex is thought to be mediated by serotonin, a specific brain chemical or neurotransmitter that is involved is transmitting nerve signals, which enables brain cells to communicate. Low levels of serotonin in certain areas of the brain are thought to be responsible for causing PE. 

Dapoxetine in Poxet blocks the re-uptake of serotonin from the synapse, which is the gap between nerve cells across which chemical messages are sent from one nerve cell to another. If the re-uptake of serotonin by the first nerve cell (pre-synaptic) is blocked, this means that there is more serotonin remaining for the receiving nerve cell (post-synaptic), which allows nerve cells to communicate with each other for longer. This action of dapoxetine in Poxet 60 helps prolong the ability to maintain sexual activity without premature ejaculation and maintain control over ejaculation for longer.

The most commonly reported side effects when taking Poxet tablets 60mg include, headache, gastrointestinal upset (nausea, diarrhoea, dry mouth, abdominal discomfort), dizziness, drowsiness, tremor, difficulty sleeping, increased blood pressure, erectile dysfunction, reduced libido.

Poxet (Dapoxetine) is provided as 30mg and 60mg strength tablets. Your physician will calculate the right dosage and advise you when to take it. Adult men treating premature ejaculation are usually told to start by taking 30mg 1 to 3 hours prior to engaging in sexual activity. Only one dosage per day (24 hours) is taken. If the 30mg strength tablets do not work well enough, go to consult your physician. It is possible that you may be instructed to take the maximum dosage (60mg per day).

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