Viraday

ABOUT VIRADAY:

- VIRADAY contains three antiretroviral active substances: efavirenz, emtricitabine, and tenofovir used to treat infection caused by the virus  Human             Immunodeficiency Virus (HIV).

- VIRADAY is intended for the treatment of infection by the human immunodeficiency virus (HIV) of adults older than 18 who have previously been treated  with other antiretroviral drugs and their HIV infection is under control for at least three months.

 DO NOT TAKE VIRADAY IF YOU:

  - Are allergic to the active substances

  - If you suffer from severe liver disease

  - If you have irregular heart rhythm

Inform your doctor if you are taking some of the listed drugs:

  - Astemizole or terfenadine

  - Bepridil

  - Methylergonovine) (used to treat migraine and cluster headaches)

  - Midazolam or triazolam (used for easier sleep)

  - Pimozide, imipramine, amitriptyline

  - Voriconazole

  - Metoprolol

  - Antibiotics (macrolides, imidazole)

  - Antimycotics containing triazole

  - Antimalarials

  - Methadone

PAY ATTENTION TO WARNINGS AND PRECAUTIONS:

  - HIV can be transmitted even while you are taking this medicine,

  - Inform your doctor if you:

  - Are taking other medicines containing lamivudine or adefovir

  - Have or have had kidney disease, or

  - Have a heart disorder,

  - Have ever had a mental illness, including depression,

  - Have had convulsions

  - Have been taking carbamazepine, phenobarbital, and phenytoin.

  - If you have ever had liver disease

  - If you are over 65 years of age

 HOW TO TAKE VIRADAY?

  -The recommended dose is: One tablet a day applied to your mouth. VIRADAY should be taken on an empty stomach 1 hour before or 2 hours after meals

  VIRADAY must be taken every day.

  - If you take more VIRADAY than you need:

 - If you accidentally take too many VIRADAYa tablets, you may be at increased risk of side effects

 - Associated with this medicine (Ask a doctor for advice or

 - The nearest emergency medical service. Take a bottle of tablets with you.

 - If you forget to take VIRADAY

 - It's important that you do not miss taking a dose of VIRADAYa.

 THE INTERACTION WITH THER DRUGS:

  Inform your doctor if you are taking some of these medicines:

  - For HIV infection: darunavir, indinavir, lopinavir/ritonavir,

  - For hepatitis C infection: boceprevir, sofosbuvir...

  - Atorvastatin, pravastatin, simvastatin.

  - Anticonvulsants:  carbamazepine, phenytoin, phenobarbital.

  - Antibiotics and antituberculotics: clarithromycin, rifabutin, rifampicin.

  - Antimycotics: itraconazole or posaconazole

  - Antimalarials: atovaquone / proguanil

  - Hormonal contraceptives

  - Antidepressives:

  - Immunosuppressives: cyclosporin, sirolimus or tacrolimus.

  - Warfarin or acenocoumarol

WHAT ARE POSSIBLE SIDE EFFECTS?

  • Swelling of the face, lips, tongue or throat

  • Psychological disorders:, suicidal thoughts, paranoia, mood changes, hallucinations),

  • Pancreatitis

  • Epileptic seizures, trembling

  • Liver or kidney damage

  • Inflammation of the kidneys, urinary large quantities of urine and feeling of thirst

  • Back pain caused by kidney problems, including kidney failure.

  • Bone softening (with bone pain and sometimes consequent fractures

  • Fat liver

  • Difficulty sleeping, abnormalities, concentration problems, infertility

  • Problems with digestion feeling of numbness and flatulence

  • Loss of appetite

  • Changes in skin color, including spot skin tones that often begin with fists